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CQMS Advantage

Over several years, CINRG developed a standardized muscle strength testing system called the CINRG Quantitative Measurement System (CQMS). This system integrates anthropometrics, muscle, pulmonary, functional and timed tests into one system with direct data entry to increase accuracy and efficiency. CQMS quantitative muscle testing portion is a modification of the Tufts Quantitative Neuromuscular Testing Equipment designed for Amyotrophic Lateral Sclerosis (ALS) clinical trials. This quantitative muscle testing (QMT) technique collects measurements of force using a load cell while performing a maximum voluntary isometric contraction. This set-up is able to measure changes in strength of 0.25 pounds and thereby provides accurate and sensitive force generation measurement, especially in children. Additionally, a QMT system interfaced with audiovisual feedback was developed as it was found that in effort dependent tests, it is important to provide motivation to yield the greatest efforts by participants. In essence, the audiovisual feedback interface turns the strength measurement process into a 'video game', leading to increased compliance and effort (reliability). Reliability of measures ensures that similar responses of effort during each test are achieved.

Currently, CINRG uses the CINRG Quantitative Measurement System to assess muscle strength, function and respiratory measures. These measures are standardized and used throughout the multicenter, multinational design of the network. Some of the assessments used for clinical trials include:

Anthropometric Evaluation
Limb Lengths
Range of Motion Evaluation
Elbow Flexion/Extension
Knee flexion/Extension
Ankle Dorsiflexion
Wrist extension
Strength Testing
Manual Muscle Testing
Quantitative Strength Testing
   Hip Abduction/Adduction
   Elbow Flexion/Extension
   Knee flexion/Extension
   Hand Grip
   Pinch Grip
Pulmonary Function Tests
Forced Vital Capacity (FVC)
Maximum Inspiratory Pressure (MIP)
Maximum Expiratory Pressure (MEP
Peak Cough
Timed Function Tests
Time to Stand from Supine
Time to Climb 4 Standard Stairs
30 Meter Walk
6 Minute Walk Test
Functional Grading
Brooke Upper Extremity Scale
Vignos Lower Extremity Scale
Egen Klassifikation (EK) Scale

CINRG is constantly searching for improved methods and measures to more accurately gauge a patient's disease progression and has been at the forefront of research in clinical outcome measures. For more information on CQMS please contact us at


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